Uperio 100mg is a combination medication that contains Sacubitril and Valsartan, specifically designed for the management of heart failure with reduced ejection fraction (HFrEF). This innovative therapy works through dual mechanisms to enhance heart function and reduce the risk of cardiovascular events.

Indications:

• Treatment of heart failure with reduced ejection fraction (HFrEF) in adults.
• Used to decrease the risk of cardiovascular death and hospitalization due to heart failure.

Dosage: The usual starting dose is 50mg (sacubitril 24mg and valsartan 26mg) twice daily, which may be adjusted based on the patient’s response and tolerability. Always follow a healthcare provider’s recommendations regarding dosage.

Mechanism of Action: Uperio combines Sacubitril, which inhibits neprilysin (an enzyme that breaks down natriuretic peptides), with Valsartan, an angiotensin II receptor blocker. This combination leads to increased levels of beneficial peptides that promote vasodilation, improve sodium excretion, and reduce strain on the heart.

Benefits:

• Effectively improves heart function and alleviates symptoms of heart failure.
• Reduces the risk of hospitalization and cardiovascular mortality.
• Convenient twice-daily dosing regimen.

Side Effects: Common side effects may include low blood pressure (hypotension), high potassium levels (hyperkalemia), dizziness, cough, and renal impairment. Serious side effects, such as angioedema, are rare but require immediate medical attention. Patients should discuss any concerns with their healthcare provider.

Precautions:

• Use with caution in individuals with renal impairment, a history of angioedema, or those who are pregnant or breastfeeding.
• Regular monitoring of blood pressure, kidney function, and electrolyte levels is essential during treatment.

Storage: Store at room temperature, away from moisture and heat. Keep out of reach of children.

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