UPERIO VALSARTAN is a prescription medication that contains 50 mg of the active ingredient valsartan. This medication is part of a class of drugs known as angiotensin II receptor blockers (ARBs), which are commonly used in the management of high blood pressure (hypertension) and heart failure. By effectively lowering blood pressure and alleviating strain on the heart, valsartan plays a crucial role in cardiovascular health.

Indications: UPERIO VALSARTAN is indicated for several key therapeutic uses:

• Essential Hypertension: It is used in adults and children aged 6 years and older to manage high blood pressure, which can help prevent strokes, heart attacks, and kidney problems.
• Heart Failure: The medication is also prescribed for adults to manage heart failure, improving symptoms and quality of life by helping the heart pump more efficiently.
• Post-Myocardial Infarction: Valsartan is indicated for the reduction of cardiovascular morbidity in patients with left ventricular dysfunction following a heart attack, contributing to better long-term outcomes.

Mechanism of Action: Valsartan functions by selectively blocking the angiotensin II receptor. Angiotensin II is a powerful vasoconstrictor that narrows blood vessels and increases blood pressure. By inhibiting its action, valsartan leads to vasodilation (widening of blood vessels), resulting in lower blood pressure and decreased strain on the heart. This mechanism not only helps manage hypertension but also supports heart failure treatment by improving blood flow and reducing fluid retention.

Dosage and Administration: The typical starting dose for adults with hypertension is 80 mg once daily, which may be titrated up to 320 mg based on individual blood pressure response and tolerance. For pediatric patients aged 6 to 16, the dosage is determined by body weight. For heart failure management, healthcare providers may start at a lower dose and adjust as needed based on clinical response and tolerability. Always adhere to the dosing regimen prescribed by your healthcare provider, and do not adjust your dose without consulting them.

Side Effects: While UPERIO VALSARTAN is generally well tolerated, some patients may experience side effects. Common side effects include:

• Dizziness or Lightheadedness: Especially upon standing up, due to blood pressure changes.
• Fatigue: A sense of tiredness that may occur as the body adjusts to the medication.
• Headache: Some patients may experience headaches during treatment.
• Nausea or Abdominal Discomfort: Gastrointestinal symptoms can occur, although they are typically mild.
• Hyperkalemia: Elevated potassium levels can be a concern, necessitating periodic blood tests to monitor levels.

Serious side effects are rare but can include severe allergic reactions, liver problems, or kidney dysfunction. Seek immediate medical attention if you experience symptoms such as swelling, difficulty breathing, or persistent abdominal pain.

Precautions: Before starting UPERIO VALSARTAN, inform your healthcare provider of any medical history, especially:

• Pregnancy: This medication is contraindicated during pregnancy due to the risk of fetal harm.
• Renal Impairment: Dose adjustments may be necessary for individuals with kidney issues.
• Liver Disease: Caution is advised, and monitoring may be required for patients with liver dysfunction.
• Drug Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, as valsartan can interact with certain medications, such as diuretics or other antihypertensives.

Lifestyle Considerations: For optimal management of hypertension or heart failure, lifestyle modifications are recommended in conjunction with UPERIO VALSARTAN therapy. These may include:

• Diet: Adopting a heart-healthy diet low in salt, saturated fats, and sugars.
• Exercise: Regular physical activity as tolerated can help manage weight and improve cardiovascular health.
• Avoiding Tobacco and Alcohol: Reducing or eliminating tobacco use and limiting alcohol intake can enhance treatment effectiveness.
• Regular Monitoring: Regular check-ups with your healthcare provider to monitor blood pressure and assess overall cardiovascular health.

Storage: Store UPERIO VALSARTAN at room temperature, away from direct sunlight, moisture, and heat sources. Ensure that the medication is kept in its original packaging and out of reach of children to prevent accidental ingestion.

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