Pyrox Combi is a combination medication that includes rabeprazole, amoxicillin, and clarithromycin. This formulation is used to treat Helicobacter pylori infections, which are associated with peptic ulcers. It works by reducing stomach acid and eradicating the bacteria.

Indications:
Pyrox Combi is indicated for:

• Eradication of Helicobacter pylori to reduce the risk of duodenal ulcers
• Treatment of peptic ulcers associated with H. pylori infection
• Management of gastroesophageal reflux disease (GERD) in conjunction with H. pylori treatment

Mechanism of Action:

• Rabeprazole: A proton pump inhibitor (PPI) that decreases gastric acid secretion, promoting healing of the stomach lining.
• Amoxicillin: A penicillin-type antibiotic that works by inhibiting bacterial cell wall synthesis, effectively killing the bacteria.
• Clarithromycin: A macrolide antibiotic that inhibits bacterial protein synthesis, further aiding in the eradication of H. pylori.

Dosage and Administration:

• Adults: The usual dosage is one tablet taken once daily, typically for a 10 to 14-day course, or as directed by a healthcare provider.
• It is recommended to take the tablet before meals for optimal effectiveness.

Side Effects:
Common side effects may include:

• Nausea
• Diarrhea
• Abdominal pain
• Headache

Serious side effects are rare but may include:

• Allergic reactions
• Clostridium difficile-associated diarrhea
• Liver function abnormalities

Storage:
Store at room temperature, away from moisture and heat. Keep out of reach of children.

Caution:
Consult a healthcare provider before use if you are pregnant, breastfeeding, or have a history of liver or kidney issues. Complete the full course of treatment as prescribed, even if symptoms improve.

Packaging:
Typically available in blister packs or bottles, containing 14 tablets or more.

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