Buy Quetiapine 300mg Online in Nigeria – Atypical Antipsychotic for Schizophrenia and Bipolar Disorder

Buy Quetiapine 300mg online from HubPharm Africa, a PCN licensed specialty pharmacy. Quetiapine fumarate is a second generation, or atypical, antipsychotic indicated for the treatment of schizophrenia, for manic and depressive episodes in bipolar disorder, for the prevention of recurrence in bipolar disorder, and, in its prolonged release form, as adjunctive treatment of major depressive episodes.

Quetiapine 300mg is a therapeutic maintenance strength. In schizophrenia, effective doses commonly fall between 300mg and 750mg daily; in bipolar mania between 400mg and 800mg; and in bipolar depression 300mg daily is the established target dose. The strength is therefore used both as a full daily dose in bipolar depression and as a component of higher regimens elsewhere.

What makes quetiapine distinctive is that its clinical behaviour changes with dose. At low doses it is largely antihistaminergic and sedating; at moderate doses noradrenergic and serotonergic actions predominate and give antidepressant effect; only at higher doses does dopamine D2 occupancy reach the range associated with antipsychotic action. HubPharm pharmacists review every order, confirm the indication and dose, and counsel on metabolic and cardiovascular monitoring. Same-day delivery within Lagos, 48 hours nationwide.

Key Features

• Broad Licensed Range: Indicated across schizophrenia, bipolar mania, bipolar depression and recurrence prevention, and as adjunctive therapy in major depression in the prolonged release form.
• Low Extrapyramidal Burden: Quetiapine has a relatively low propensity for movement side effects compared with older antipsychotics, which is a principal reason it is used in patients sensitive to those effects.
• Established Bipolar Depression Dose: 300mg daily is the recognised target dose for bipolar depression, an indication in which few agents have robust evidence.
• Once-Daily Options: The prolonged release presentation permits once-daily evening dosing, which supports adherence in long-term treatment.
• Metabolic Monitoring Support: Our pharmacists prompt for weight, waist circumference, fasting glucose, HbA1c and lipid review, the parameters most often neglected in long-term antipsychotic care.

Frequently Asked Questions

What is quetiapine 300mg used for?

It is used in schizophrenia, in manic and depressive episodes of bipolar disorder, and for the prevention of recurrence in bipolar disorder. In the prolonged release form it is also used as add-on treatment for major depressive episodes where the response to an antidepressant alone has been inadequate.

How does quetiapine work?

Quetiapine and its active metabolite norquetiapine act at multiple receptors. Antagonism at dopamine D2 receptors underlies the antipsychotic effect, antagonism at serotonin 5-HT2A receptors reduces movement side effects, norquetiapine’s inhibition of the noradrenaline transporter and partial agonism at 5-HT1A contribute to antidepressant effect, and histamine H1 antagonism produces sedation.

Why is quetiapine described as dose dependent?

Its receptor occupancy shifts with dose. At 25mg to 100mg the histaminergic sedative effect dominates. At 150mg to 300mg noradrenergic and serotonergic actions produce antidepressant effect. Antipsychotic D2 occupancy is generally reached above 300mg. This is why the same molecule is used at very different doses for different conditions.

When should quetiapine be taken?

Immediate release quetiapine is usually taken twice daily. The prolonged release form is taken once daily, generally in the evening, at least one hour before food. Sedation is the main reason evening dosing is preferred.

What are the common side effects?

Drowsiness, dizziness, dry mouth, headache, constipation, weight gain, increased appetite, raised triglycerides and cholesterol, and orthostatic hypotension, particularly during dose escalation.

Does quetiapine cause weight gain?

Yes, weight gain and metabolic disturbance are recognised and clinically important effects. Weight, waist circumference, fasting glucose, HbA1c and lipids should be measured before starting and monitored regularly throughout treatment.

Why do I feel dizzy when I stand up?

Quetiapine blocks alpha-1 adrenergic receptors, which can cause orthostatic hypotension, especially in the first days and during dose increases. Rise slowly from sitting or lying, and report fainting or falls to your prescriber.

Can quetiapine be stopped suddenly?

No. Abrupt discontinuation can cause insomnia, nausea, headache, anxiety and irritability, and can precipitate relapse. Withdrawal should be gradual over at least one to two weeks under medical supervision.

Does quetiapine affect the heart?

Quetiapine can prolong the QT interval. Caution is needed in patients with cardiac disease, electrolyte disturbance, or on other QT-prolonging medicines. An ECG may be recommended before or during treatment in at-risk patients.

Is quetiapine safe for older adults with dementia?

Antipsychotics, including quetiapine, are associated with an increased risk of stroke and death in elderly patients with dementia-related psychosis and are not licensed for that use. Any prescribing in this group requires careful specialist justification and review.

Does quetiapine interact with other medicines?

Yes. It is metabolised by CYP3A4, so strong inhibitors such as ketoconazole and clarithromycin markedly raise its levels, while inducers such as carbamazepine, phenytoin and rifampicin reduce them substantially. Alcohol and other sedatives increase drowsiness.

Do I need a prescription to buy quetiapine in Nigeria?

Yes. Quetiapine is a prescription only medicine dispensed against a valid prescription from a physician registered in Nigeria.