Uperio 200mg is a combination medication that contains Sacubitril and Valsartan. It is used primarily for the treatment of heart failure with reduced ejection fraction (HFrEF). This innovative therapy improves heart function and reduces the risk of cardiovascular events by utilizing two complementary mechanisms.

Indications:

• Treatment of heart failure with reduced ejection fraction (HFrEF) in adults.
• Used to reduce the risk of cardiovascular death and hospitalization due to heart failure.

Dosage: The typical starting dose is 100mg (sacubitril 49mg and valsartan 51mg) twice daily, which may be adjusted based on the patient’s response and tolerability. Always follow a healthcare provider’s dosing instructions.

Mechanism of Action: Uperio combines the effects of Sacubitril, which inhibits neprilysin (an enzyme that breaks down natriuretic peptides), and Valsartan, which blocks the action of angiotensin II. This dual action leads to increased levels of beneficial peptides that promote vasodilation, natriuresis (sodium excretion), and reduced cardiac workload, effectively managing heart failure symptoms.

Benefits:

• Improves heart function and reduces the burden of heart failure.
• Decreases the risk of hospitalization and cardiovascular mortality.
• Provides a convenient dosing regimen.

Side Effects: Common side effects may include hypotension (low blood pressure), hyperkalemia (high potassium levels), cough, dizziness, and renal impairment. Serious side effects, such as angioedema, are rare but require immediate medical attention. Patients should consult their healthcare provider for a complete list of side effects.

Precautions:

• Use with caution in individuals with renal impairment, a history of angioedema, or those who are pregnant or breastfeeding.
• Regular monitoring of blood pressure, kidney function, and electrolyte levels is advised during treatment.

Storage: Store at room temperature, away from moisture and heat. Keep out of reach of children.

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