Palbocib is primarily used to treat specific types of advanced or metastatic breast cancer, specifically hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) cases.

It is a CDK4/6 inhibitor. It works by blocking specific proteins (cyclin-dependent kinases 4 and 6) that help cancer cells divide and grow. By inhibiting these, the medication slows the progression of the cancer. It is typically taken in combination with hormonal therapy, such as an aromatase inhibitor or fulvestrant.

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